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KMID : 0605820140210010022
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Korean Journal of Pediatric Infectious Diseases
2014 Volume.21 No. 1 p.22 ~ p.28
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Risk Factors Associated with Respiratory Virus Detection in Infants Younger than 90 Days of Age
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Eem Yeun-Joo
Bae E-Young
Lee Jung-Hyun
Jeong Chang-Mo
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Abstract
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Purpose: This study aimed at determining the detection rate of respiratory viruses and at investigating the risk factors associated with respiratory virus detection in young infants.
Methods: From September 2011 to August 2012, nasopharyngeal swabs were obtained from 227 infants aged ≤90 days with suspected infectious diseases, including sepsis. We performed a retrospective analysis of their clinical characteristics. The prevalence of respiratory viruses in their nasopharyngeal swabs was assayed by real-time polymerase chain reaction (real-time PCR).
Results: In total, 157 (69.2%) infants had more than one of the following respiratory viruses: respiratory syncytial virus (n= 75), rhinovirus (n=42), influenza virus (n=18), parainfluenza virus (n=15), human metapneumovirus (n=9), coronavirus (n=9), adenovirus (n=4), and bocavirus (n=3). During the same period, bacterial infections were confirmed in 24 infants (10.6%). The detection of respiratory viruses was significantly associated with the presence of cough, a family history of respiratory illness, and a seasonal preference (fall/winter). Using logistic regression analysis, these 3 variables were also identified as significant risk factors. During fall and winter, detection of respiratory viruses was significantly higher in infants who did not have a bacterial infection.
Conclusion: Respiratory virus is an important pathogen in young infants admitted to a hospital, who are suspected with infectious diseases. Detection of respiratory viruses in young infants was associated with seasonality (fall/winter), presence of respiratory symptoms and a family history of respiratory illness.
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KEYWORD
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Infants, Nasopharynx, Virus disease, Respiratory tract infections, Real-time polymerase chain reaction
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